723 research outputs found

    Are People Really Concerned About Their Privacy?: Privacy Paradox In Mobile Environment

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    The wide spread of mobile devices enables people to use the Internet everywhere. It provides people convenience in various aspects. However, they also are exposed to the risk of personal information leakage and privacy invasion. No previous study has examined whether the behaviors of people are influenced by their awareness of privacy in a mobile environment. With the ever-increasing importance of privacy issues, our study examines the critical relationship between individual privacy concerns and its behavior. The data is the media diary or 10,174 individuals’ media usage for three days, collected by the Korea Information Society Development Institute (KISDI) in 2014. Our result suggests that privacy concern has a positive influence on the smartphone usage, mobile application purchase and in-app purchase. It implies that the individual privacy concern does not correspond to his or her actual behaviors, which is paradoxical

    High-resolution, reconfigurable printing of liquid metals with three-dimensional structures

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    We report an unconventional approach for high-resolution, reconfigurable 3D printing using liquid metals for stretchable, 3D integrations. A minimum line width of 1.9 ??m can be reliably formed using direct printing, and printed patterns can be reconfigured into diverse 3D structures with maintaining pristine resolutions. This reconfiguration can be performed multiple times, and it also generates a thin oxide interface that can be effective in preventing the spontaneous penetration of gallium atoms into different metal layers while preserving electrical properties under ambient conditions. Moreover, these free-standing features can be encapsulated with stretchable, conformal passivations. We demonstrate applications in the form of a reconfigurable antenna, which is tunable by changing geometeries, and reversibly movable interconnections used as mechanical switches. The free-standing 3D structure of electrodes is also advantageous for minimizing the number and space between interconnections, which is important for achieving higher integrations, as demonstrated in an array of microLEDs

    Study on parasite effect with strapdown seeker in consideration of time delay

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    Retrieval of NO2 Column Amounts from Ground-Based Hyperspectral Imaging Sensor Measurements

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    Total column amounts of NO2 (TCN) were estimated from ground-based hyperspectral imaging sensor (HIS) measurements in a polluted urban area (Seoul, Korea) by applying the radiance ratio fitting method with five wavelength pairs from 400 to 460 nm. We quantified the uncertainty of the retrieved TCN based on several factors. The estimated TCN uncertainty was up to 0.09 Dobson unit (DU), equivalent to 2.687 ?? 1020 molecules m???2) given a 1?? error for the observation geometries, including the solar zenith angle, viewing zenith angle, and relative azimuth angle. About 0.1 DU (6.8%) was estimated for an aerosol optical depth (AOD) uncertainty of 0.01. In addition, the uncertainty due to the NO2 vertical profile was 14% to 22%. Compared with the co-located Pandora spectrophotometer measurements, the HIS captured the temporal variation of the TCN during the intensive observation period. The correlation between the TCN from the HIS and Pandora also showed good agreement, with a slight positive bias (bias: 0.6 DU, root mean square error: 0.7 DU)

    M3FPolypSegNet: Segmentation Network with Multi-frequency Feature Fusion for Polyp Localization in Colonoscopy Images

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    Polyp segmentation is crucial for preventing colorectal cancer a common type of cancer. Deep learning has been used to segment polyps automatically, which reduces the risk of misdiagnosis. Localizing small polyps in colonoscopy images is challenging because of its complex characteristics, such as color, occlusion, and various shapes of polyps. To address this challenge, a novel frequency-based fully convolutional neural network, Multi-Frequency Feature Fusion Polyp Segmentation Network (M3FPolypSegNet) was proposed to decompose the input image into low/high/full-frequency components to use the characteristics of each component. We used three independent multi-frequency encoders to map multiple input images into a high-dimensional feature space. In the Frequency-ASPP Scalable Attention Module (F-ASPP SAM), ASPP was applied between each frequency component to preserve scale information. Subsequently, scalable attention was applied to emphasize polyp regions in a high-dimensional feature space. Finally, we designed three multi-task learning (i.e., region, edge, and distance) in four decoder blocks to learn the structural characteristics of the region. The proposed model outperformed various segmentation models with performance gains of 6.92% and 7.52% on average for all metrics on CVC-ClinicDB and BKAI-IGH-NeoPolyp, respectively.Comment: 5pages. 2023 IEEE International Conference on Image Processing (ICIP). IEEE, 202

    ZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts

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    Various stresses, including oxidative stress, impair the proliferative capacity of muscle stem cells leading to declined muscle regeneration related to aging or muscle diseases. ZNF746 (PARIS) is originally identified as a substrate of E3 ligase Parkin and its accumulation is associated with Parkinson’s disease. In this study, we investigated the role of PARIS in myoblast function. PARIS is expressed in myoblasts and decreased during differentiation. PARIS overexpression decreased both proliferation and differentiation of myoblasts without inducing cell death, whereas PARIS depletion enhanced myoblast differentiation. Interestingly, high levels of PARIS in myoblasts or fibroblasts induced cellular senescence with alterations in gene expression associated with p53 signaling, inflammation, and response to oxidative stress. PARIS overexpression in myoblasts starkly enhanced oxidative stress and the treatment of an antioxidant Trolox attenuated the impaired proliferation caused by PARIS overexpression. FoxO1 and p53 proteins are elevated in PARIS-overexpressing cells leading to p21 induction and the depletion of FoxO1 or p53 reduced p21 levels induced by PARIS overexpression. Furthermore, both PARIS and FoxO1 were recruited to p21 promoter region and Trolox treatment attenuated FoxO1 recruitment. Taken together, PARIS upregulation causes oxidative stress-related FoxO1 and p53 activation leading to p21 induction and cellular senescence of myoblasts. © 2020, The Author(s).1

    Characterization of nit sheath protein functions and transglutaminase-mediated cross-linking in the human head louse, Pediculus humanus capitis

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    Background Head louse females secrete liquid glue during oviposition, which is solidified to form the nit sheath over the egg. Recently, two homologous proteins, named louse nit sheath protein (LNSP) 1 and LNSP 2, were identified as adhesive proteins but the precise mechanism of nit sheath solidification is unknown. Methods We determined the temporal transcriptome profiles of the head louse accessory glands plus oviduct, from which putative major structural proteins and those with functional importance were deduced. A series of RNA interference (RNAi) experiments and treatment of an inhibitor were conducted to elucidate the function and action mechanism of each component. Results By transcriptome profiling of genes expressed in the louse accessory glands plus uterus, the LNSP1 and LNSP2 along with two hypothetical proteins were confirmed to be the major structural proteins. In addition, several proteins with functional importance, including transglutaminase (TG), defensin 1 and defensin 2, were identified. When LNSP1 was knocked down via RNA interference, most eggs became nonviable via desiccation, suggesting its role in desiccation resistance. Knockdown of LNSP2, however, resulted in oviposition failure, which suggests that LNSP2 may serve as the basic platform to form the nit sheath and may have an additional function of lubrication. Knockdown of TG also impaired egg hatching, demonstrating its role in the cross-linking of nit sheath proteins. The role of TG in cross-linking was further confirmed by injecting or hair coating of GGsTop, a TG inhibitor. Conclusions Both LNSP1 and LNSP2 are essential for maintaining egg viability besides their function as glue. The TG-mediated cross-linking plays critical roles in water preservation that are essential for ensuring normal embryogenesis. TG-mediated cross-linking mechanism can be employed as a therapeutic target to control human louse eggs, and any topically applied TG inhibitors can be exploited as potential ovicidal agents. Graphical abstractThis work was supported by a grant from the National Institutes of Health/National Institute for Allergy and Infectious Disease (5R01AI045062-06) to JM Clark and SH Lee. DE Lee was supported in part by the Brain Korea 21 Plus program

    Comparison of The Genome Profiles Between Head and Body Lice

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    The body louse (Pediculus humanus humanus) is known to have diverged from the head louse (P. humanus capitis) but genomic differences between these two subspecies still remain unexplored. To compare genomic profiles between head and body lice, whole genome sequences of head lice were determined by next generation sequencing methods based on both Illumina Genome analyzer and Roche GS FLX pyrosequencing and compared with the reference genome sequences of the body louse. Total consensuses generated by mapping to the body louse genome in conjunction with de novo assembly of head louse genome sequences revealed a head louse genome size of 110 Mbp with a 96% coverage of the body louse genome sequences. A total of 12,651 genes were predicted from the head louse genome sequences although more precise assembly and functional annotation of the genome is required for a more accurate gene count. Among the 873 genes that were putatively specific to the head louse, 15 genes were confirmed to be transcribed in both head and body lice, suggesting the previously estimated gene number of the body louse was likely underestimated. The single nucleotide polymorphism analysis showed that the nucleotide diversity of genome between head and body lice was 2.2%, which was larger than that of the transcriptome between head and body lice. An endosymbiont genome analysis showed that the composition of endosymbionts in head lice was similar to that of body lice and Candidatus Riesia pediculicola was the primary endosymbiont in both head and body lice
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